Antiviral Activity of Thiazolide Derivatives Against Dengue Virus in Huh-7 Cell Line

Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2.

Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis and antiviral activity evaluation of two compounds based on the quinoline scaffold, which has shown potential for the development of molecules with various biolog...

Antiviral Activity of Emetine Dihydrochloride Against Dengue Virus Infection

Dengue fever has become a global concern as dengue infections are prevalent in the tropics and the subtropics, and can lead to a severe life-threatening illness. Currently, there is a widespread interest to search for vaccine or antiviral therapy to combat DENV infection. In this study, we have identified emetine dihydrochloride with potent antiviral activity against DENV infection. Emetine was...

Novel antiviral activity of baicalein against dengue virus

BACKGROUND Dengue is a serious arboviral disease currently with no effective antiviral therapy or approved vaccine available. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the natural compounds, bioflavonoids derived mainly from plants are of interest because of their biological and medicinal benefits. METHODS In the present study, ...

Antiviral Immunity against Dengue Virus The Roles of IRF-3 and IRF-7 in Innate

In vitro antiviral activity of Fisetin, Rutin and Naringenin against Dengue virus type-2

In vitro antiviral activities of three flavonoids; fisetin, naringenin and rutin against DENV-2 (NGC strain) were evaluated. Inhibitory effects of each compound at the different stages of DENV-2 infection were examined using foci forming unit reduction assay (FFURA) and quantitative real-time polymerase chain amplification (qRT-PCR). Fisetin, rutin and naringenin showed cytotoxic effects agains...